Pediatr Infect Dis J. 2020 Dec 30;Publish Ahead of Print. doi: 10.1097/INF.0000000000003038. Online ahead of print.
Pediatric infective endocarditis incurs significant morbidity and generally occurs among children with underlying heart disease. Identification of a pathogen is critical in determining appropriate therapy. However, standard diagnostic testing has limited sensitivity. We describe a case series of children with infective endocarditis in whom plasma next-generation sequencing (Karius, Redwood, CA) identified an organism in 8 of 10 cases.