Prefrontal cortex modulation of stress by primary cilia

Neuron. 2025 Apr 16;113(8):1126-1128. doi: 10.1016/j.neuron.2025.03.026.

ABSTRACT

In this issue of Neuron, Yang et al.¹ reveal that primary cilia in mouse prefrontal cortex excitatory neurons regulate stress responses via cAMP/PKA signaling. Stress induces ciliary elongation, enhancing corticosterone-mediated neuronal inhibition. Cilia loss reduces stress sensitivity, highlighting their role in stress adaptation, with potential therapeutic relevance.

PMID:40245842 | DOI:10.1016/j.neuron.2025.03.026