Detecting Extrachromosomal DNA from Routine Histopathology
bioRxiv [Preprint]. 2026 Mar 2:2026.02.27.708546. doi: 10.64898/2026.02.27.708546. ABSTRACT Extrachromosomal DNA (ecDNA) is a major driver of oncogene amplification, tumour heterogeneity and poor clinical outcomes [1-3], yet its detection relies on specialised genomic assays that are not integrated into routine diagnostics. Here, we show that ecDNA status can be inferred directly from standard haematoxylin and eosin-stained […]
Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence
Nat Commun. 2025 Dec 10. doi: 10.1038/s41467-025-67257-8. Online ahead of print. ABSTRACT Estrogen receptor-positive breast cancer remains a leading cause of cancer-related death in women, with mortality largely driven by late recurrence of treatment-resistant disease. Loss of MLH1 promotes resistance to estrogen-targeting therapies by uncoupling cell cycle progression from estrogen regulation. Here, we show that […]